How Adaptogens Work on the Stress Axis
Adaptogens normalize HPA axis activity rather than simply suppressing cortisol. Here is the mechanism behind the key adaptogens and how they differ from each other.
Adaptogens normalize HPA axis activity rather than simply suppressing cortisol. Here is the mechanism behind the key adaptogens and how they differ from each other.
KSM-66 ashwagandha, phosphatidylserine, rhodiola, L-theanine, and magnolia bark have clinical evidence for reducing cortisol. Here is the data.
Honokiol and magnolol in magnolia bark modulate GABA receptors and reduce cortisol. Here is the evidence for anxiety, sleep, and stress applications.
Phosphatidylserine blunts exercise-induced cortisol spikes, improves HPA feedback, and supports cognitive function. Here is the clinical evidence and optimal dosing.
Chronically elevated cortisol damages sleep, muscle, and immune function. These adaptogens and nutrients have clinical evidence for normalizing the HPA axis.