Alpha-Ketoglutarate for Anti-Aging: The Human RCT
A human RCT showed calcium alpha-ketoglutarate reversed biological age by 8 years on the Horvath clock. Here is what the evidence shows.
February 27, 2026·5 min read
Anti-Aging Antioxidants: Which Ones Actually Work?
Not all antioxidants are equal for longevity. Here is the evidence-based guide to antioxidants that genuinely slow biological aging.
February 27, 2026·5 min read
Autophagy-Inducing Supplements: Boost Your Body's Self-Cleaning System
Autophagy removes cellular waste and is central to longevity. These supplements stimulate autophagy to slow biological aging.
February 27, 2026·4 min read
Supplements That Induce Autophagy: Spermidine and Beyond
A guide to supplements that activate autophagy, including spermidine, berberine, EGCG, and urolithin A, with evidence rankings.
February 27, 2026·5 min read
Blue Zone Secrets: What Supplements Can We Learn from the World's Longest-Lived People?
Blue Zone populations live exceptional lives. Here is what their diet and lifestyle reveal about the best supplements for longevity.
February 27, 2026·4 min read
Caloric Restriction Mimetics: Supplements That Mimic Fasting Effects
Caloric restriction mimetics activate the same longevity pathways as fasting without hunger. Here are the best-studied compounds.
February 27, 2026·4 min read
Cellular Senescence: How Supplements Can Clear Zombie Cells
Senescent cells accumulate with age and drive inflammation. These supplements and strategies help clear them to slow biological aging.
February 27, 2026·5 min read
Supplements That May Slow the Epigenetic Clock
Alpha-ketoglutarate, NMN, spermidine, and other supplements with evidence for slowing biological aging at the epigenetic level.
February 27, 2026·5 min read
Fisetin for Longevity: Senolytic Activity and Brain Protection
Fisetin clears senescent cells, protects neurons, and extends lifespan in mice. Here is what the human evidence shows and how to dose it.
February 27, 2026·5 min read
Fisetin: The Most Potent Natural Senolytic for Anti-Aging
Fisetin clears senescent cells more effectively than most natural compounds. Here is what the science shows about this powerful flavonoid.
February 27, 2026·4 min read
The 12 Hallmarks of Aging: Which Supplements Target Each
A research-backed map of the 12 hallmarks of aging and the specific supplements that target each biological process.
February 27, 2026·5 min read
HMB for Preventing Muscle Loss With Age: Evidence Review
HMB is a leucine metabolite that reduces muscle protein breakdown with age. Here is an honest look at the evidence, dosing, and value compared to leucine.
February 27, 2026·5 min read
Inflammaging: The Best Supplements to Fight Inflammation and Aging
Chronic low-grade inflammation drives aging. These science-backed supplements reduce inflammaging to extend healthspan and longevity.
February 27, 2026·4 min read
Longevity Biomarkers: How to Track Aging and Use Supplements Strategically
Testing biological age biomarkers lets you use supplements strategically. Here is how to measure and optimize your aging rate.
February 27, 2026·5 min read
Longevity Supplement Stack for Men: A Practical Protocol
A complete longevity supplement protocol for men, with morning and evening split, dosing guidance, and the evidence behind each component.
February 27, 2026·4 min read
Longevity Supplement Stack for Women: A Practical Protocol
A phased longevity supplement protocol for women, addressing hormonal changes, bone health, and cellular aging with evidence-based dosing.
February 27, 2026·4 min read
The Complete Guide to Longevity Supplements in 2026
A comprehensive look at the top science-backed longevity supplements, how they work, and how to stack them effectively.
February 27, 2026·4 min read
Metformin for Anti-Aging: Evidence, Controversies, and Alternatives
Metformin is a diabetes drug being studied as the first anti-aging pharmaceutical. Here is what the current evidence shows.
February 27, 2026·4 min read
Mitochondria and Longevity: The Best Supplements for Mitochondrial Health
Mitochondrial decline drives aging. These supplements support mitochondrial function, biogenesis, and energy production at any age.
February 27, 2026·5 min read
mTOR Inhibitors for Longevity: Natural and Pharmaceutical Options
Inhibiting mTOR is one of the most robust longevity interventions known. Here are the best natural and pharmaceutical options available.
February 27, 2026·4 min read
NMN Supplements: The Complete Longevity Guide
Everything you need to know about NMN supplementation for longevity — dosing, timing, research, and how to maximize results.
February 27, 2026·4 min read
Nicotinamide Riboside (NR): Science-Backed Guide to NAD+ Boosting
NR is one of the best-studied NAD+ precursors for longevity. Learn the research, dosing, and how it compares to NMN.
February 27, 2026·4 min read
Natural Rapamycin Alternatives: mTOR Inhibition Without the Drug
Rapamycin is the most consistent longevity drug in animal models. These supplements partially mimic its mTOR-inhibiting effects — with honest limits on the comparison.
February 27, 2026·5 min read
Rapamycin for Longevity: What You Need to Know in 2026
Rapamycin is the most studied longevity drug. Here is an honest look at the evidence, risks, and who should consider it.
February 27, 2026·4 min read
Natural Senolytic Supplements: Clearing Zombie Cells
Natural senolytics including fisetin, quercetin, and EGCG can help clear senescent cells. Here is the evidence ranked against the dasatinib + quercetin benchmark.
February 27, 2026·5 min read
Sirtuins and Longevity: How to Activate Them with Supplements
Sirtuins are a family of longevity proteins activated by NAD+ and certain polyphenols. Learn how to support them with targeted supplements.
February 27, 2026·4 min read
Spermidine: The Autophagy Supplement Backed by Longevity Science
Spermidine induces autophagy and has extended lifespan in multiple organisms. Here is the complete guide to this longevity supplement.
February 27, 2026·4 min read
Spermidine for Longevity: Autophagy, Memory, and Aging
A deep dive into spermidine's role in autophagy, memory protection, and longevity — including optimal doses and food sources.
February 27, 2026·5 min read
Supplements for Age Spots: Reduce Hyperpigmentation from Within
Age spots are driven by oxidative stress and UV damage. These evidence-backed supplements can reduce hyperpigmentation and prevent new spots.
February 27, 2026·4 min read
Supplements to Prevent Age-Related Bone Loss
Bone loss accelerates with age and drives fractures that shorten healthspan. This guide covers the evidence-based supplement stack for bone preservation.
February 27, 2026·5 min read
Supplements for Cardiovascular Health With Aging
Cardiovascular disease remains the leading cause of death with age. These supplements have the strongest evidence for protecting heart health in older adults.
February 27, 2026·5 min read
Supplements to Protect Against Cognitive Decline With Age
Cognitive decline is not inevitable. These supplements have the strongest evidence for protecting brain function and reducing dementia risk with age.
February 27, 2026·5 min read
Supplements for Cognitive Aging: Protect Your Brain as You Age
Cognitive decline is not inevitable. These evidence-backed supplements support brain health, memory, and mental clarity through aging.
February 27, 2026·5 min read
Supplements to Prevent and Reverse Age-Related Hair Loss
Hair loss with age has multiple nutrient deficiency and hormonal components. These supplements have the strongest evidence for hair preservation and regrowth.
February 27, 2026·5 min read
Supplements for Healthspan vs Lifespan: Different Goals
Healthspan and lifespan are not the same goal. Here is how supplement strategies differ depending on whether you want to live better or live longer.
February 27, 2026·5 min read
The Best Supplements for Healthy Aging After 50
After 50, specific nutritional needs shift. Here are the most important supplements for maintaining strength, cognition, and vitality.
February 27, 2026·4 min read
Supplements for Hormonal Changes With Aging
Hormone levels decline with age in both men and women. These supplements offer evidence-based support for testosterone, estrogen metabolism, and adrenal health.
February 27, 2026·5 min read
Supplements for Immune Aging (Immunosenescence)
Immunosenescence — the decline of immune function with age — increases infection risk and cancer susceptibility. These supplements have the best evidence for immune support.
February 27, 2026·5 min read
Starting Longevity Supplements at 40: What to Prioritize
Your 40s are the optimal time to build a longevity supplement foundation. Here is what to start with and in what order, based on current evidence.
February 27, 2026·5 min read
Longevity Supplements for People Over 60: Priority Ranking
After 60, the supplement priority order changes. Here is an evidence-based ranking of longevity supplements most relevant for adults over 60.
February 27, 2026·5 min read
Supplements to Prevent Age-Related Muscle Loss (Sarcopenia)
Sarcopenia is one of the primary drivers of frailty and mortality with age. These supplements have the strongest evidence for preserving muscle.
February 27, 2026·5 min read
The Best Supplements for Skin Aging: Collagen, Antioxidants, and More
Skin aging is both visible and reversible with the right supplements. Here is what the research shows for collagen, wrinkles, and radiance.
February 27, 2026·5 min read
Taurine for Longevity: The 2023 Science Study Explained
A 2023 Nature study found taurine decline drives aging across species. Here is what the research shows about taurine and longevity.
February 27, 2026·5 min read
Supplements That Support Telomere Length and Cellular Aging
Telomere length is a key marker of biological aging. Discover which supplements have evidence for protecting and extending telomeres.
February 27, 2026·4 min read
Urolithin A: The Gut-Derived Longevity Molecule
Urolithin A activates mitophagy and improves muscle function with age. Here is what the clinical evidence shows about dosing and sources.
February 27, 2026·5 min read
Alpha-Ketoglutarate: TCA Cycle Support and Longevity Evidence
Alpha-ketoglutarate is a TCA cycle intermediate with emerging longevity evidence including a human trial showing reduced biological age.
February 26, 2026·4 min read
AMPK Activators: Supplements That Switch On Your Longevity Gene
AMPK is the master energy sensor that drives longevity. Learn which supplements activate it and the doses that have human evidence.
February 26, 2026·4 min read
Anti-Aging Supplement Stack for Men: Complete Protocol by Decade
A decade-by-decade guide to the most evidence-backed anti-aging supplements for men, from your 30s through your 70s.
February 26, 2026·5 min read
The Complete Biohacking Stack: Morning to Night Longevity Protocol
A comprehensive, evidence-based longevity supplement protocol organized by time of day—covering NAD+, senolytics, mitochondria, and inflammation.
February 26, 2026·5 min read
Fisetin: The Most Promising Natural Senolytic
Fisetin clears senescent cells and is emerging as the most potent natural senolytic. Here is the Mayo Clinic research, the dosing protocol, and honest caveats.
February 26, 2026·6 min read
Geroprotectors: Supplements That Slow the Biology of Aging
Geroprotectors target the fundamental mechanisms of aging rather than individual diseases. A comprehensive guide to evidence-based options.
February 26, 2026·4 min read
Supplements to Prevent Glycation: AGE Formation and Anti-Aging
Advanced glycation end-products (AGEs) cross-link proteins and accelerate aging. These supplements reduce AGE formation and break existing bonds.
February 26, 2026·4 min read
The Longevity Supplement Stack: What to Take in 2026
A science-based breakdown of the longevity supplement stack for 2026, from NAD+ precursors and senolytics to what Bryan Johnson actually takes.
February 26, 2026·7 min read
Supplements for Mitochondrial Biogenesis: Making New Mitochondria
Mitochondrial biogenesis—making new mitochondria—declines with age. PGC-1alpha activators and these supplements restore mitochondrial capacity.
February 26, 2026·4 min read
Natural mTOR Inhibition: Supplements That Mimic Rapamycin
Rapamycin extends lifespan in every organism tested. These natural compounds partially mimic its mTOR-inhibiting effects without a prescription.
February 26, 2026·4 min read
NAD+ vs NMN vs NR: Which Supplement Actually Works?
NMN and NR both raise NAD+ levels, but differ in absorption, cost, and evidence. Here is a head-to-head breakdown.
February 26, 2026·4 min read
NAD+: Why It Declines With Age and How to Restore It
NAD+ drops 50% by midlife. Learn why this coenzyme is central to aging and which supplements actually restore it.
February 26, 2026·4 min read
NMN vs. NR: Which NAD+ Precursor Is Better in 2026?
Both NMN and NR raise NAD+ levels in humans, but through slightly different pathways. Here's what the 2026 evidence shows and an honest take on longevity claims.
February 26, 2026·6 min read
PQQ (Pyrroloquinoline Quinone): Mitochondrial and Cognitive Benefits
PQQ is unique among vitamins: it stimulates new mitochondria formation and acts as a potent antioxidant with human evidence for cognitive and metabolic benefits.
February 26, 2026·4 min read
Proteostasis Supplements: Protein Quality Control and Longevity
Proteostasis—keeping proteins properly folded and functional—declines with age. These supplements support the machinery that clears damaged proteins.
February 26, 2026·4 min read
Pterostilbene vs Resveratrol: The Better Stilbene?
Pterostilbene has better bioavailability than resveratrol and stronger evidence for cognitive and metabolic benefits. Here is the comparison.
February 26, 2026·4 min read
Rapamycin for Longevity: What the Evidence Shows
Rapamycin is the most reproducible life-extension compound in animal studies. Here is what the human evidence shows and what is unknown.
February 26, 2026·4 min read
Resveratrol: Sirtuin Activation, Bioavailability, and Evidence
Resveratrol activates sirtuins and mimics caloric restriction—but poor bioavailability limits its potential. Here is what the evidence shows.
February 26, 2026·4 min read
Senolytic Supplements: Clearing Zombie Cells for Longevity
Senescent cells accumulate with age and drive tissue dysfunction. Senolytics clear them—here is the complete guide to senolytic supplements.
February 26, 2026·4 min read
Sirtuin Activators: NAD+, Resveratrol, and the Anti-Aging Enzymes
Sirtuins are NAD+-dependent enzymes that regulate aging. Learn how to activate them with the right supplements and lifestyle interventions.
February 26, 2026·4 min read
Supplements That Trigger Autophagy: Fasting Mimetics
Autophagy is the cellular cleanup process. These fasting mimetic supplements activate autophagy pathways without requiring extended fasting.
February 26, 2026·4 min read
Supplements for Cellular Health: DNA Repair and Cell Function
DNA damage accumulates with age and drives cellular dysfunction. These supplements support the repair machinery that maintains genomic integrity.
February 26, 2026·4 min read
Supplements for DNA Repair: Niacin, Vitamin D, and Antioxidants
DNA repair capacity declines with age and drives cancer and cellular dysfunction. These supplements support the repair machinery at multiple levels.
February 26, 2026·5 min read
Longevity Supplements for Men: Hormones, Heart, and Brain
Men face unique longevity challenges: testosterone decline, cardiovascular risk, and cognitive aging. This protocol addresses all three.
February 26, 2026·5 min read
Longevity Supplements for Women: Hormones, Bone, and Brain
Evidence-based longevity supplements for women targeting hormonal aging, bone density, cognitive preservation, and cardiovascular health across the lifespan.
February 26, 2026·6 min read
Supplements for Mitochondrial Health: Fueling Your Cellular Powerhouses
CoQ10, NAD+ precursors, L-carnitine, PQQ, and more—here is the evidence hierarchy for mitochondrial health supplements and how to prioritize them.
February 26, 2026·6 min read
Supplements for Stem Cell Health: Urolithin A, Spermidine, and More
Stem cell exhaustion is a hallmark of aging. These supplements support the regenerative capacity that keeps tissues young and functional.
February 26, 2026·5 min read
Supplements for Telomere Health and Cellular Aging
Telomere length is a biomarker of cellular aging. These supplements have evidence for reducing telomere attrition and supporting telomerase.
February 26, 2026·4 min read
Supplements for Telomere Health: What Actually Works
Telomere shortening is a hallmark of aging, but most telomere supplements lack evidence. Here is what the science actually supports.
February 26, 2026·4 min read
Resveratrol Benefits: Longevity and Health Guide
Discover the science-backed benefits of resveratrol for longevity, heart health, and anti-aging. Learn optimal dosing, best sources, and how to maximize absorption.
February 15, 2026·15 min read